CTO Pathophysiology: How Does this Affect Management?

ISSN: 1875-6557 (Online)
ISSN: 1573-403X (Print)

Volume 11, 4 Issues, 2015

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Current Cardiology Reviews

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Jian'an Wang
School of Medicine Zhejiang University

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CTO Pathophysiology: How Does this Affect Management?

Current Cardiology Reviews, 10(2): 99-107.

Author(s): John Irving.

Affiliation: Ninewells Hospital, Dundee UK.


Chronic total occlusion (CTO) pathophysiology has been described in a few, small studies using post mortem histology, and more recently, in vivo intravascular ultrasound (IVUS) to analyse the constituents of occluded segments. Recent improvements in equipment and techniques have revealed new insights into physical characteristics of occluded coronaries, which in turn enable predictable procedural success. The purpose of this review is to consider the published evidence describing CTO pathophysiology from the perspective of the hybrid algorithm approach to CTO PCI.

Methods: Literature searches using “Chronic Occlusion”, “angioplasty”, and” pathology” as keywords. Further searches on “coronary” “collateral”, “Viability”. Bibliographies were scrutinised for further key publications in an iterative process. Papers describing animal models were excluded.


Angioplasty, chronic total occlusion, collateral, pathophysiology.

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Article Details

Volume: 10
Issue Number: 2
First Page: 99
Last Page: 107
Page Count: 9
DOI: 10.2174/1573403X10666140331142349

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