Cellular and Pharmacological Targets to Induce Coronary Arteriogenesis

ISSN: 1875-6557 (Online)
ISSN: 1573-403X (Print)

Volume 13, 4 Issues, 2017

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Current Cardiology Reviews

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Jian'an Wang
School of Medicine Zhejiang University

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Cellular and Pharmacological Targets to Induce Coronary Arteriogenesis

Current Cardiology Reviews, 10(1): 29-37.

Author(s): Maurits R. Hollander, Anton J.G. Horrevoets and Niels van Royen.

Affiliation: VU University Medical Center, Department of Cardiology, Room 4D-36, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.


The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different factors. Although animal studies on collateral formation and stimulation show promising data, clinical trials have failed to replicate these results. Further research to the exact mechanisms is needed in order to develop a pharmalogical stimulant. This review gives an overview of recent data in the field of arteriogenesis.


Arteriogenesis, CAD, collateral, endothelium, growth factors, proliferation, SMC.

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Article Details

Volume: 10
Issue Number: 1
First Page: 29
Last Page: 37
Page Count: 9
DOI: 10.2174/1573403X113099990003

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