Plants Used in Traditional Medicine: Extracts and Secondary Metabolites Exhibiting Antileishmanial Activity
Luiz Felipe Domingues Passero, Márcia D. Laurenti, Gabriela Santos-Gomes, Bruno Luiz Soares Campos, Patrícia Sartorelli and João Henrique G. LagoAffiliation:
Laboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo 455, 01246-903, São Paulo, Brazil
AbstractPlants and their extracts have been used traditionally against different pathologies, and in some poor regions they are the only therapeutic source for treatments. Moreover, the identification of specific active secondary metabolites can be account for amelioration of clinical status of suffering individual. A series of ethnopharmacological surveys conducted in Brazil recorded the traditional use of plants against different pathologies and interestingly, some of them presented antileishmanial activity in vitro and in vivo, possibly due to their immunostimulatory, healing and microbicidal properties. Of note, Leishmania parasites can alter patient’s immunological status, leading to the development of extensive skin and/or visceral alterations. Therefore, the extracts or secondary metabolites presented in plants that might be capable of improving the pathological conditions can be attractive candidates in the development of new chemotherapeuticals against leishmaniosis.
Chemotherapy, leishmaniasis, medicinal plants, secondary metabolites
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