Medicinal Chemistry of New Compounds to Treat Tuberculosis

ISSN: 2212-3938 (Online)
ISSN: 1574-8847 (Print)

Volume 12, 4 Issues, 2017

Download PDF Flyer

Current Clinical Pharmacology

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Arduino A. Mangoni
Flinders University and Flinders Medical Centre
Adelaide, SA

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Medicinal Chemistry of New Compounds to Treat Tuberculosis

Current Clinical Pharmacology, 10(2): 139-159.

Author(s): Marina Candido Primi, Natanael Dante Segretti and Elizabeth Igne Ferreira.

Affiliation: Laboratory of Design and Synthesis of Chemotherapeutic Potentially Active against Neglected Diseases, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo – FCF/USP Av. Prof. Lineu Prestes, 580 05508-900 Sao Paulo-SP, Brazil.


Tuberculosis (TB), a 19th century disease, is still present in the beginning of the Third Millennium. It has been considered pandemic, since around two billion people are infected with M. tuberculosis. Multi-drug resistant TB has been the biggest challenge for chemotherapy. In order to face this severe health problem, many institutions, private and public ones, have been investing in the search for new and better drug candidates. The pipeline of potential anti-TB drugs presents new molecules and formulations that have been submitted to pre-clinical and clinical assays. Medicinal Chemistry has an important role towards the objective of finding new leads through classic and modern processes. This paper reviews some aspects of this search, emphasizing the features of the main compounds under investigation and those that are in preliminary and final clinical trials and includes the contribution of our laboratory (LAPEN) in the area of designing new anti-TB drug candidates.


Anti-TB pipelines, designing anti-TB drug candidates, LAPEN contribution, natural products, new anti-TB candidates, new anti-TB leads, tuberculosis.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 10
Issue Number: 2
First Page: 139
Last Page: 159
Page Count: 21
DOI: 10.2174/1574884708666131229125103
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science