Vanadium Complexes with Hydrazone or Thiosemicarbazone Ligands as Potential Anti-Mycobacterium Tuberculosis Agents

ISSN: 2212-3938 (Online)
ISSN: 1574-8847 (Print)


Volume 9, 4 Issues, 2014


Download PDF Flyer




Current Clinical Pharmacology

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Arduino A. Mangoni
Flinders University and Flinders Medical Centre
Adelaide, SA
Australia


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Vanadium Complexes with Hydrazone or Thiosemicarbazone Ligands as Potential Anti-Mycobacterium Tuberculosis Agents

Author(s): Paula C. de Souza, Pedro I. S. Maia, Heloisa B. de Barros, Clarice Q. F. Leite, Victor M. Deflon and Fernando R. Pavan

Affiliation: Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, 14801-902, Araraquara, SP, Brazil

Abstract

Tuberculosis (TB) is an infectious disease caused mainly by Mycobacterium tuberculosis (MTB) and still an important public health problem worldwide. Factors like the emergence of multidrug resistant (MDR) and extensively drug-resistant (XDR) strains, makes urgent the search for new active compounds. Searching for new inorganic compounds against TB, three new dioxovanadium(V) complexes were obtained upon reaction of [VO(acac)2] with hydrazone and thiosemicarbazone ligands derived from di-2-pyridyl ketone. Spectroscopic studies and X-ray crystallography revealed asymmetrically oxo bridged binuclear complexes of the type [{VO(L1,2)}2(μ-O)2], involving the hydrazone ligands, while a mononuclear square pyramidal complex of the type [VO2(L3)] was formed with the thiosemicarbazone ligand. The compounds were tested against M. tuberculosis and three of them, with MICs values between 2.00 and 3.76 µM were considered promising for TB treatment. Such MIC values are comparable or better than those drugs currently used in TB treating


Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 8
First Page: 1
Page Count: 1
DOI: 10.2174/1574884708666131229124748
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science