A Method for Measuring Activity Difference of Phenolic and Non-Phenolic Groups through ABTS Radical Cation

ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)


Volume 17, 10 Issues, 2014


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Combinatorial Chemistry & High Throughput Screening

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A Method for Measuring Activity Difference of Phenolic and Non-Phenolic Groups through ABTS Radical Cation

Author(s): Nusrat Masood and Suaib Luqman

Affiliation: Molecular Bioprospection Department, Biotechnology Division, CSIR-Central Institute of Medicinal & Aromatic Plants, Lucknow-226015, India

Abstract

We have optimized a 2, 2`azino-bis-(3-ethyl-benzothiazoline-6-sulphonate) radical cation assay procedure to be performed in 96 well plates and evaluated the scavenging potential of phenolic and non-phenolic group of molecules with respect to control. Behaviour of molecules with ABTS radical cation has been studied and the influence of structure and concentration on the bleaching of the stable bluish green ABTS radical cation complex formation is depicted. Experimentally, it was observed that phenolic molecules showed higher reactivity with ABTS radical than non-phenolic molecules because of resonance and hyperconjugation effect


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Article Details

Volume: 17
First Page: 1
Page Count: 1
DOI: 10.2174/1386207317666140605110401
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