Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)


Volume 17, 10 Issues, 2014


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Combinatorial Chemistry & High Throughput Screening

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Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

Author(s): Afsar Ali Siddiki, Vinod Kumar Bairwa and Vikas N. Telvekar

Affiliation: Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Mumbai 400 019, India.

Abstract

A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.

Keywords: Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.

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Article Details

Volume: 17
Issue Number: 7
First Page: 630
Last Page: 638
Page Count: 9
DOI: 10.2174/1386207317666140314092412
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