Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)

Volume 16, 9 Issues, 2016

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Current Cancer Drug Targets

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Ruiwen Zhang
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106

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Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

Current Cancer Drug Targets, 14(4): 357-370.

Author(s): Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier.

Affiliation: INSERM U 837 Faculte de Medecine, 1, place Verdun F- 59045 Lille Cedex, France.


In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.


Glycolysis, mitochondria, oxidative stress, warburg.

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Article Details

Volume: 14
Issue Number: 4
First Page: 357
Last Page: 370
Page Count: 14
DOI: 10.2174/1568009614666140407113124
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