Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)


Volume 14, 9 Issues, 2014


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Texas Tech University Health Sciences Center
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Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

Author(s): Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier

Affiliation: INSERM U 837 Faculte de Medecine, 1, place Verdun F- 59045 Lille Cedex, France.

Abstract

In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.

Keywords: Glycolysis, mitochondria, oxidative stress, warburg.

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Article Details

Volume: 14
Issue Number: 4
First Page: 357
Last Page: 370
Page Count: 14
DOI: 10.2174/1568009614666140407113124
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