Glucose Transport and Metabolism in Sertoli Cell: Relevance for Male Fertility

ISSN: 1872-3136 (Online)
ISSN: 2212-7968 (Print)

Volume 11, 2 Issues, 2017

Download PDF Flyer

Current Chemical Biology

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Fernando Albericio
Department of Organic Chemistry
University of Barcelona

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Glucose Transport and Metabolism in Sertoli Cell: Relevance for Male Fertility

Current Chemical Biology, 7(3): 282-293.

Author(s): Tania R. Dias, Ana D. Martins, Vania P. Reis, Silvia Socorro, Branca M. Silva, Marco G. Alves and Pedro F Oliveira.

Affiliation: Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6201-506 Covilha, Portugal.


Sertoli cells (SCs) are essential for the testis functional development and hence for the expression of male phenotype. They provide a unique and protected environment in testis, within the seminiferous tubules, necessary for the successful progression of germ cells into fully competent spermatozoa. SC has the ability to metabolize various substrates, but preferentially uses glucose that is converted to pyruvate and lactate. This is a crucial event since lactate is essential for germ cells survival and development due to its anti-apoptotic effect and its role as energy source. Glucose metabolism in SCs is under the complex control of several hormones, predominantly sex steroid hormones, thyroid hormones (THs): follicle- stimulating hormone (FSH) and insulin. This process may occur without the requirement of protein synthesis, suggesting a modulation of enzyme activity and/or regulation of glucose transport. The transport of glucose through the plasma membrane contributes to the modulation of lactate secretion by SCs and is mediated by specific carriers. There are two different families of glucose transport proteins: the Sodium Dependent Glucose Transporters (SGLTs) and the Glucose Transporters (GLUTs): which act in a very distinct manner. The maintenance of spermatogenesis in vivo and the male fertility capacity requires a metabolic cooperation between SCs and germ cells. Indeed, an alteration in SCs ability to metabolize glucose would be expected to compromise the energy supplies to germ cells and subsequently male fertility. Herein, we discuss the regulatory molecular mechanisms of glucose transport and metabolism in SC as well as their relevance for male fertility.


Germ cells, glucose metabolism, glucose transport, lactate, sertoli cells, spermatogenesis.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 7
Issue Number: 3
First Page: 282
Last Page: 293
Page Count: 12
DOI: 10.2174/2212796807999131128125510
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science