Assessing the Validity of QSARs for Ready Biodegradability of Chemicals: An Applicability Domain Perspective

ISSN: 1875-6697 (Online)
ISSN: 1573-4099 (Print)


Volume 10, 4 Issues, 2014


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Subhash C. Basak
Departments of Chemistry, Biochemistry & Molecular Biology University of Minnesota Duluth
Duluth, MN 55811
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Assessing the Validity of QSARs for Ready Biodegradability of Chemicals: An Applicability Domain Perspective

Author(s): Faizan Sahigara, Davide Ballabio, Roberto Todeschini and Viviana Consonni

Affiliation: Milano Chemometrics and QSAR Research Group, Department of Earth and Environmental Sciences, University of Milano-Bicocca, P.za della Scienza 1 - 20126 Milano, Italy.

Abstract

Several classical and two recently proposed Applicability Domain (AD) approaches were implemented on a set of three classification models retrieved from a published study to assess the ready biodegradability of chemicals. Each model was associated with an optimal AD approach based on its ability to a) retain maximum test molecules within the model’s AD, b) be appropriate for the strategy used towards model development and c) show reasonably converging results with those derived with other AD approaches used. A decision criterion was also set to evaluate the AD of two consensus models that were developed in the original study. An overview of test molecules excluded from the AD of all the five biodegradability models was provided including an attempt to identify the major structural features and molecular descriptors possibly relevant in deciding upon their ready biodegradability. Apart from the test set, an overview of the results derived on the external validation set molecules was provided.

Keywords: Applicability domain, biodegradability, local-centred mahalanobis distance, model validation, QSAR.

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Article Details

Volume: 10
Issue Number: 2
First Page: 137
Last Page: 147
Page Count: 11
DOI: 10.2174/1573409910666140410110241
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