Influenza Pandemic Early Warning Research on HA/NA Protein Sequences
Current Bioinformatics, 9
): 228-233.Author(s): Jie Gao
, Ling Zhang
and Peixuan Jin
School of Science, Jiangnan University, Wuxi 214122, China.
AbstractUsing CGR-walk model, this paper studies influenza virus HA/NA protein sequences from 1914 to 2012, and figures out multiple early warning signal values of influenza pandemic outbreak. The variances and lag 2 autocorrelation coefficients of protein sequences obtained according to the detailed HP model of the epidemic outbreak years and the last two years are significantly higher than those of the last adjacent years, while there is not the feature in the non-epidemic years.
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