Trends in Genome Compression

ISSN: 2212-392X (Online)
ISSN: 1574-8936 (Print)

Volume 12, 6 Issues, 2017

Download PDF Flyer

Current Bioinformatics

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 0.77
5 - Year: 0.93

Trends in Genome Compression

Current Bioinformatics, 9(3): 315-326.

Author(s): Sebastian Wandelt, Marc Bux and Ulf Leser.

Affiliation: Knowledge Management in Bioinformatics, Institute for Computer Science, Humboldt-Universität zu Berlin, Germany.


Technological advancements in high throughput sequencing have led to a tremendous increase in the amount of genomic data produced. With the cost being down to 2,000 USD for a single human genome, sequencing dozens of individuals is an undertaking that is feasible even for a smaller projects or organizations established. However, generating the sequence is only one issue; another one is storing, managing, and analyzing it. These tasks become more and more challenging due to the sheer size of the data sets and are increasingly considered to be the major bottlenecks in larger genome projects. One possible countermeasure is to compress the data; compression reduces costs in terms of requiring less hard disk storage and in terms of requiring less bandwidth if data is shipped to large compute clusters for parallel analysis. Accordingly, sequence compression has recently attracted much interest in the scientific community. In this paper, we explain the different basic techniques for sequence compression, point to distinctions between different compression tasks (e.g., genome compression versus read compression), and present a comparison of current approaches and tools. To further stimulate progress in genome compression research, we also identify key challenges for future systems.


Genome compression, read compression, survey.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 9
Issue Number: 3
First Page: 315
Last Page: 326
Page Count: 12
DOI: 10.2174/1574893609666140516010143
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science