Metabolic Control Analysis and its Applications

ISSN: 2212-392X (Online)
ISSN: 1574-8936 (Print)


Volume 9, 5 Issues, 2014


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Editor-in-Chief:
Alessandro Giuliani
Istituto Superiore di Sanitá (Italian NIH) Environment and Health Dept
Roma
Italy


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Metabolic Control Analysis and its Applications

Author(s): Ana Meireles and Manuel Simoes

Affiliation: LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.

Abstract

Metabolic Engineering (ME) provides the know-how for the reconstruction of microorganisms, in order to provide higher production rates of biotechnological products and increase their potential application in several industries, particularly those pharmaceutical, food and environmental. However, microbial metabolic cell reconstruction has limitations. Metabolic Control Analysis (MCA) allows the evaluation of the reliability of the changes performed by ME, emphasizing the importance of the whole pathways rather than individual pathway reactions resulting from simple flux analysis. This led to an increased emphasis on the regulatory structure of the network. The use of MCA becomes indispensable to quantify metabolic parameters, particularly those related with direct genetic modifications. However, this type of analysis is not a common practice. In the present study MCA is exemplified as a tool of ME, being demonstrated its practical application in drug delivery and in the production of three relevant biotechnological products (penicillin V, llysine and glycerol).

Keywords: Control coefficient, drug delivery, enzyme, glycerol, kinetics, l-lysine, metabolic control analysis, penicillin V.

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Article Details

Volume: 9
Issue Number: 5
First Page: 490
Last Page: 498
Page Count: 9
DOI: 10.2174/1574893609666140515230435
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