The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines

ISSN: 1875-6646 (Online)
ISSN: 1573-4072 (Print)


Volume 10, 4 Issues, 2014


Download PDF Flyer




Current Bioactive Compounds

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines

Author(s): Adriano Mollica, Francesco Pinnen, Stefanucci Azzurra and Roberto Costante

Affiliation: Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy.

Abstract

Peptides and proteins have been known for more than a century, but was only when du Vigneaud published the first synthesis of oxytocin, that the research on bioactive peptides was truly launched. Since then, the scientific progresses in the field have been astonishing and the synthesis of peptides of virtually any size and complexity is now possible. Perhaps the most important milestone was the development of the solid-phase peptide synthesis (SPPS) by Merrifield (1963), to revolutionize the field. In this critic review, we will analyze how the SPPS contributed to widespread the manufacture of peptides as active pharmaceuticals and what will be the challenges of tomorrow in this field.

Keywords: SPPS, LPPS, fmoc-chemistry, molecular machine, native chemical ligation.

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 9
Issue Number: 3
First Page: 184
Last Page: 202
Page Count: 19
DOI: 10.2174/157340720903140119151919
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science