Design, Synthesis and Evaluation of Antibacterial Activity of Novel Indazole Derivatives

ISSN: 1875-6646 (Online)
ISSN: 1573-4072 (Print)

Volume 13, 4 Issues, 2017

Download PDF Flyer

Current Bioactive Compounds

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Design, Synthesis and Evaluation of Antibacterial Activity of Novel Indazole Derivatives

Current Bioactive Compounds, 9(4): 263-269.

Author(s): Anuruddha Chabukswar, Bhanudas Kuchekar, Pradeep Lokhande, Mangesh Tryambake, Bharat Pagare, Vinayak Kadam, Swati Jagdale and Vasant Chabukswar.

Affiliation: MAEER'S Maharashtra Institute of Pharmacy, Kothrud, Pune-411038, Maharashtra, India.


A series of novel indazole derivatives have been designed and synthesized by a novel method and evaluated for their antibacterial activity. The compounds were designed to study their interactions as inhibitor of DNA gyrase B. Salicylaldehyde and hydrazine hydrate have been refluxed along with polyethylene glycol and catalytic amount of ptoluenesulfonic acid to yield desired compounds. All the synthesized compounds were subjected to in vitro anti-bacterial activity studies against B. Subtilis, S. aureus, E. coli, P. Aeruiginosa and S. typhi. Substituted compounds I5, I9 and I13 exhibited significant inhibition of bacterial growth. The MIC value of these 3 compounds was found to be 50µ g/mL. Compounds substituted at 5th and 6th position of indazole were found to show better hydrogen bond interactions with DNA gyrase B and appreciable potential for anti-bacterial activity. They can be used as potential molecule in bacterial resistance cases. The present studies will be useful for designing selective compounds for inhibition of DNA gyrase B.


Hydrazine hydrate, minimum inhibitory concentration, polyethylene glycol, p-toluenesulfonic acid, salicylaldehyde.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 9
Issue Number: 4
First Page: 263
Last Page: 269
Page Count: 7
DOI: 10.2174/1573407209999131231095550
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science