Rivastigmine for Refractory REM Behavior Disorder in Mild Cognitive Impairment

ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)

Volume 12, 10 Issues, 2015

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Current Alzheimer Research

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Prof. Debomoy K. Lahiri
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202

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Rivastigmine for Refractory REM Behavior Disorder in Mild Cognitive Impairment

Current Alzheimer Research, 11(3): 267-273.

Author(s): Valerio Brunetti, Anna Losurdo, Elisa Testani, Leonardo Lapenta, Paolo Mariotti, Camillo Marra, Paolo Maria Rossini and Giacomo Della Marca.

Affiliation: Institute of Neurology, Catholic University, Rome, Italy.


Background: Mild Cognitive Impairment (MCI) and REM Behavior Disorder (RBD) are both associated with a degeneration of ponto-medullary cholinergic pathways. Methods: We conducted a placebo-controlled, cross-over pilot trial of Rivastigmine (RVT) in 25 consecutive patients with MCI, who presented RBD refractory to conventional first-line treatments (melatonin up to 5 mg/day and clonazepam up to 2 mg/day). Results: RVT treatment was followed by a significant reduction of RBD episodes when compared with placebo. Conclusions: Our data suggest that, in MCI patients with RBD resistant to conventional therapies (muscle relaxants benzodiazepines or melatonin,) treatment with RVT may induce a reduction in the frequency of RBD episodes compared to placebo.


Acetylcholine, acetylcholinesterase inhibitors, Alzheimer disease, cholinergic pathways, MCI, mild cognitive impairment, RBD, REM behavior disorder, REM, rivastigmine (RVT), sleep.

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Article Details

Volume: 11
Issue Number: 3
First Page: 267
Last Page: 273
Page Count: 7
DOI: 10.2174/1567205011666140302195648

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