Impaired Renal Function and Biomarkers of Vascular Disease in Alzheimer’s Disease

ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)

Volume 14, 12 Issues, 2017

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Current Alzheimer Research

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Prof. Debomoy K. Lahiri
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202

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Impaired Renal Function and Biomarkers of Vascular Disease in Alzheimer’s Disease

Current Alzheimer Research, 11(3): 253-258.

Author(s): Cassandra Richardson, Ramin Nilforooshan, Paul R. Gard, Gary Weaving and Naji Tabet.

Affiliation: Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9RR, UK.


Renal disease is a risk factor for vascular diseases and for dementia, and renal insufficiency can be a feature of Alzheimer’s disease (AD). Evidence has suggested that vascular mechanisms mediate the link between renal disease and dementia. Our study sought to test this hypothesis by examining renal and vascular functioning in AD by investigating estimated glomerular filtration rates (eGFR), calculated from serum creatinine concentrations, and established biomarkers of vascular functioning, asymmetrical dimethylarginine (ADMA) and plasma homocysteine (Hcy), in individuals with mild to moderate AD (n = 34) and a group of older adult controls (n = 34). We found significantly reduced eGFR, indicative of impaired renal functioning, in individuals with AD (M = 62.9, SD = 15.2) compared with controls (M = 73.6, SD = 11.8). However, concentrations of ADMA and Hcy did not differ between patient and control groups (ADMA: M = 0.47; M = 0.50; Hcy: M = 17.2; M = 14.9; patients and controls). The criteria for a mediation analysis were not met, as concentrations of ADMA and Hcy did not predict AD, indicating that these biomarkers of vascular functioning did not mediate a relationship between renal functioning and AD. This study indicated that renal insufficiency may independently contribute to AD pathology, and other vascular mechanisms may influence a relationship between renal impairment and AD.


Alzheimer’s disease, asymmetrical dimethylarginine, biomarkers of vascular disease, glomerular filtration rate, homocysteine, renal disease.

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Article Details

Volume: 11
Issue Number: 3
First Page: 253
Last Page: 258
Page Count: 6
DOI: 10.2174/1567205011666140131121739
Price: $58

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