Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease

ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)


Volume 11, 10 Issues, 2014


Download PDF Flyer




Current Alzheimer Research

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 38th of 194 in Clinical Neurology
  • 80th of 251 in Neurosciences

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Prof. Debomoy K. Lahiri
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.796
5 - Year: 3.998

Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease

Author(s): Epameinondas Lyros, Constantinos Bakogiannis, Yang Liu and Klaus Fassbender

Affiliation: Department of Neurology, University of the Saarland, Kirrberger Str. 1, 66421 Homburg/Saar, Germany.

Abstract

Alzheimer’s disease (AD) is characterized by a progressive decline of cognitive functions and represents the most common form of dementia and a major cause of morbidity and mortality in the modern, westernized societies. There is accumulating evidence to support the hypothesis that a primary cerebral vascular dysfunction initiates a cascade of events that lead to neuronal injury in Alzheimer’s dementia. The endothelium, in specific, constitutes a part of the blood brain barrier, the dysfunction of which is thought to play an important role to disturbed amyloid-β homeostasis and infiltration of the brain parenchyma with circulating toxic molecules in the disease. Furthermore, the endothelium itself is under certain conditions capable of producing neurotoxic and inflammatory factors, whereas common growth factors regulate the development and maintenance of both neurons and blood vessels. Reliance of both endothelial and neuronal cells on mitochondrial integrity and common molecular pathways for apoptosis also imply that there is a link between vascular pathology and neurodegeneration. The present article intends to review available evidence on molecular players implicated in the above mechanisms with the potential to develop biomarkers or novel therapeutic targets.

Keywords: Alzheimer's disease, dementia, endothelium, vascular, β -amyloid.

Download Free Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 1
First Page: 18
Last Page: 26
Page Count: 9
DOI: 10.2174/1567205010666131119235254
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science