Impaired Cerebral Autoregulation and Vasomotor Reactivity in Sporadic Alzheimer’s Disease

ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)

Volume 12, 10 Issues, 2015

Download PDF Flyer

Current Alzheimer Research

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 34th of 192 in Clinical Neurology
  • 69th of 252 in Neurosciences

Submit Abstracts Online Submit Manuscripts Online

Prof. Debomoy K. Lahiri
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.889
5 - Year: 3.933

Impaired Cerebral Autoregulation and Vasomotor Reactivity in Sporadic Alzheimer’s Disease

Current Alzheimer Research, 11(1): 11-17.

Author(s): Aisha S.S. Meel-van den Abeelen, Joep Lagro, Arenda H.E.A. van Beek and Jurgen AHR Claassen.

Affiliation: Radboud University Medical Center, Department of Geriatric Medicine, 925, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.


Background Understanding the relationship between vascular disease and Alzheimer’s disease (AD) will enhance our insight into this disease and pave the way for novel therapeutic research. Cerebrovascular dysfunction, expressed as impaired cerebral autoregulation and cerebral vasomotor reactivity, has been observed in transgenic mouse models for AD. Translation to human AD is limited and conflicting however. Objective To investigate if impaired cerebral autoregulation and cerebral vasomotor reactivity, found in animal models for AD, are present in human sporadic AD. Methods In 12 patients with mild to moderate AD (75 SD 4 yr) and 24 controls matched for age and history of hypertension, all without diabetes, we measured blood pressure (Finapres) and cerebral blood flow-velocity (transcranial Doppler). Cerebral autoregulation was assessed during changes in blood pressure induced by single and repeated sit-stand maneuvers. Cerebral vasomotor reactivity was assessed during hyperventilation and inhalation of 5 % carbon dioxide. Results During single sit-stands, controls had a 4% (SD 8) decrease in cerebrovascular resistance during a reduction in blood pressure, and an 8 % (SD 11) increase during a rise in blood pressure, indicating normal cerebral autoregulation. These changes were not seen in AD (p=0.04). During repeated sit-stands, blood pressure fluctuated by 20 % of baseline. This led to larger fluctuations in cerebral blood flow in AD (27 (6) %) than in controls (22 (6) %, p < 0.05). Cerebral vasomotor reactivity to hypercapnia was reduced in AD (42.7 % increase in CBFV, versus 79.5 % in controls, p = 0.03). Conclusion Observations of impaired cerebrovascular function (impaired autoregulation and vasoreactivity) in transgenic mouse models for AD were confirmed in patients with sporadic AD.


Cerebral circulation, cerebral amyloid angiopathy, transcranial doppler, Alzheimer’s disease.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 1
First Page: 11
Last Page: 17
Page Count: 7
DOI: 10.2174/1567205010666131119234845

Related Journals

Webmaster Contact: Copyright © 2015 Bentham Science