Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography

ISSN: 1875-6727 (Online)
ISSN: 1573-4110 (Print)


Volume 10, 4 Issues, 2014


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Current Analytical Chemistry

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Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography

Author(s): Xiao-Qing Chen, Cong-Hao Sun, Fei-Peng Jiao, Jin-Gang Yu and Xin-Yu Jiang

Affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.

Abstract

Extremely good enantioseparation of a kind of commonly used β-blockers, (±)-propranolol, has been achieved on silica gel layers which were impregnated with β-cyclodextrin and oxidized multi-walled carbon nanotubes. Solvent system tert-butenol-acetonitrile (1:1, v/v) successfully resolved the enantiomers of (±)-propranolol. The spots were detected at 254 nm with a UV lamp. The effect of concentration of the mobile phase variation was also studied.

Keywords: Enantioseparation, propranolol, β-cyclodextrin, oxidized multi-walled carbon nanotubes, thin-layer chromatography.

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Article Details

Volume: 10
Issue Number: 2
First Page: 267
Last Page: 270
Page Count: 4
DOI: 10.2174/15734110113090990028
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