Zinc-Aceclofenac Complex: Synthesis, Hydrolysis Study and Antiinflammatory Studies

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 13, 3 Issues, 2014


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey


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Zinc-Aceclofenac Complex: Synthesis, Hydrolysis Study and Antiinflammatory Studies

Author(s): Mayura A. Kale, Rupesh Shelke and Rajesh B. Nawale

Affiliation: Government College of Pharmacy, opposite Government Polytechnic, Railway station road, Osmanpura, Aurangabad (M.S) 431-005, India.

Abstract

Aceclofenac, a nonsteroidal anti-inflammatory drug, has a propensity to cause gastric ulcers, while zinc ions are known to possess anti-ulcer and anti-inflammatory activities. With a view to reduce the gastroenteropathies associated with aceclofenac, its zinc complex was prepared and characterized using spectroscopy and differential scanning calorimetry. In vitro hydrolysis study showed that zinc complex of aceclofenac is more stable in HCl buffer (pH 1.2) than in phosphate buffer (pH 7.4) indicating the stability of the complex in stomach. In silico testing of the aceclofenac and its complex using PASS (Prediction of activity spectra of substances) software revealed that the complex might possess antiinflammatory activity which was confirmed by carrageenan-induced rat paw edema test. It has been found that antiinflammatory activity of this complex is comparable with that of parent drug along with reduction in ulcer index. Thus, the use of complex is suggested to be more preferable than aceclofenac alone.

Keywords: Anti-inflammatory, anti-ulcer & PASS, ulcer index, zinc-aceclofenac complex.

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Article Details

Volume: 13
Issue Number: 1
First Page: 36
Last Page: 44
Page Count: 9
DOI: 10.2174/1871523013999140130121134
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