Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 13(2): 128-138.

Author(s): Laxmikant H. Nitlikar, Jaiprakash N. Sangshetti and Devanand B Shinde.

Affiliation: Avra Laboratories Private Limited, Hyderabad 500076, A.P. India.

Abstract

A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their antiinflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents.




Keywords:

Azoles, α-Aryl propionic acid, non-steroidal anti-inflammatory drugs, rat paw edema, suzuki cross-coupling reaction.



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Article Details

Volume: 13
Issue Number: 2
First Page: 128
Last Page: 138
Page Count: 11
DOI: 10.2174/1871523012666131224110834
Price: $58
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