Synthesis and Antibacterial Activity of Some Novel 1-(4-Oxo-3-(3- methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 12, 2 Issues, 2014


Download PDF Flyer




Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Synthesis and Antibacterial Activity of Some Novel 1-(4-Oxo-3-(3- methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides

Author(s): V. Alagarsamy, B. Arun kumar, P. Parthiban, R. V. Sheorey and V. Raja Solomon

Affiliation: Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy, Gr. Hyderabad.

Abstract

A new series of novel 1-(4-oxo-3-(3-methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides were synthesized by the reaction of 2-hydrazino-3-(3-methoxyphenyl) quinazolin-4(3H)-one with various methyl esters of dithiocarbamic acid. When tested for their in vitro antitubercular activity using H37Rv strain on Middle brook 7H11 agar slants with OADC growth supplement, all the test compounds inhibited the growth of Mycobacterium tuberculosis at microgram concentration. Among the test compounds, three compounds 1-(4-oxo-3-(3-methoxy phenyl)-3H-quinazolin-2-yl)-4-(thiazol- 2-yl) thiosemicarbazide (A1), 1-(4-oxo-3-(3-methoxyphenyl)-3H-quinazolin-2-yl)-4-(4-chlorophenyl) thiosemi-carbazide (A6) and 1-(4-oxo-3-(3-methoxyphenyl)-3H-quinazolin-2-yl)-4-(4-nitrophenyl) thiosemicarbazide (A7) were inhibited at the 6 μg/mL concentration. The title compounds are also screened for the antimicrobial activity against some other gram positive and gram negative bacteria by agar dilution method, compounds A6 and A7 were emerged as the most active compounds of the series. Compound A6 showed most potent activity against E. coli, K. pneumoniae and B. subtilis.

Keywords: Antitubercular, quinazolinone, thiosemicarbazide, anti-bacterial

Purchase Online Rights and Permissions

Article Details

Volume: 10
Issue Number: 2
First Page: 105
Last Page: 110
Page Count: 6
DOI: 10.2174/2211362611208020105
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science