A Review on Antiproliferative and Apoptotic Activities of Natural Honey
Anti-Cancer Agents in Medicinal Chemistry, 15
Saravana Kumar Jaganathan, Arunpandian Balaji, Muthu Vignesh Vellayappan, Manjesh Kumar Asokan, Aruna Priyadharshni Subramanian, Agnes Aruna John, Eko Supriyanto, Saiful Izwan Abd Razak and Mohsen MarvibaigiAffiliation:
IJN-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, University Teknologi Malaysia, Johor Bahru 81310, Malaysia.
AbstractRecent statistics revealed that cancer is one among the main reasons for death throughout the world. Several treatments are available but still there is no cure when it is detected at late stages. One of the treatment modes for cancer is chemotherapy which utilizes anticancer drugs in order to eradicate the cancer cells by apoptosis. Apoptosis is a programmed cell death through which body maintains homeostasis or kills cancer cells by utilizing its cell machinery. Recent researches have concluded that dietary agents have a putative role in instituting apoptosis of cancer cells. Honey, one of the victuals rich in antioxidants, has a long-standing exposure to humans and its role in cancer prevention and treatment is a topic of current interest. Various researchers have been experimenting honey against different cancers and provided valuable insights about the apoptosis induced by the honey. This review will highlight the recent findings of apoptotic mechanism involved in different cancer cells. Further it also reports antitumor activity of honey in some animal models. Hence it is high-time to initiate more preclinical trials as well as clinical experiments which would further add to the knowledge of anticancer nature of honey and also endorse honey as a potential candidate in the war against cancer.
Antiproliferative, antitumor, apoptosis, cancer, honey.
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