Recent Developments on Thiourea Based Anticancer Chemotherapeutics

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 15, 10 Issues, 2015


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 29th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Recent Developments on Thiourea Based Anticancer Chemotherapeutics

Author(s): Vikas Kumar and Swapandeep Singh Chimni

Affiliation: Department of Chemistry, U.G.C. Center of Advance Studies in Chemistry, Guru Nanak Dev University, Amritsar-143005, India.

Abstract

The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.




Keywords: Anticancer chemotherapeutics, carbonic anhydrase (CA) inhibitors, protein tyrosine kinase inhibitors, sirtuins inhibitors, thiourea, somatostatin agonists, topoisomerase inhibitors.

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Article Details

Volume: 15
Issue Number: 2
First Page: 163
Last Page: 175
Page Count: 13
DOI: 10.2174/1871520614666140407123526
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