Baicalin Induces Apoptosis of Gallbladder Carcinoma Cells in Vitro Via a Mitochondrial-Mediated Pathway and Suppresses Tumor Growth in Vivo

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 14, 10 Issues, 2014


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Baicalin Induces Apoptosis of Gallbladder Carcinoma Cells in Vitro Via a Mitochondrial-Mediated Pathway and Suppresses Tumor Growth in Vivo

Author(s): Yi-Jun Shu, Run-Fa Bao, Xiang-Song Wu, Hao Weng, Qian Ding, Yang Cao, Mao-Lan Li, Jia-Sheng Mu, Wen-Guang Wu, Qi-Chen Ding, Tian-Yu Liu, Lin Jiang, Yun-Ping Hu, Zhu-Jun Tan, Peng Wang and Ying-Bin Liu

Affiliation: Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine

Abstract

Baicalin, the main active ingredient in the Scutellaria baicalensis (SB), is prescribed for the treatment of various inflammatory diseases and tumors in clinics in China. In the present study, we evaluated the antitumor activity of baicalin for gallbladder carcinoma and the underlying mechanisms both in vitro and in vivo. Our results indicate that baicalin induced potent growth inhibition, cell cycle arrest, apoptosis and colony-formation inhibition in a dose-dependent manner in vitro. We observed inhibition of NF-κB nuclear translocation, up-regulation of Bax and down-regulation of Bcl-2, as well as increased caspase-3 and caspase-9 expression after baicalin treatment in vitro and in vivo, which indicates that the mitochondrial pathway was involved in baicalin-induced apoptosis. In addition, daily intraperitoneally injection of baicalin (15, 30 and 60 mg/kg) for 21 days significantly inhibited the growth of NOZ cells xenografts in nude mice, which improved the survival of baicalin-treated mice. In summary, baicalin exhibited a significant anti-tumor effect by suppressing cell proliferation, promoting apoptosis, and inducing cell cycle arrest in vitro, and by suppressing tumor growth and improving survival in vivo, which suggested that baicalin represents a novel therapeutic option for gallbladder carcinoma


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Article Details

Volume: 14
First Page: 1
Last Page: 1
Page Count: 1
DOI: 10.2174/1871520614666140223191626
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