Microtubule-targeting Anticancer Agents from Marine Natural Substance

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 15, 10 Issues, 2015

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 29th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Microtubule-targeting Anticancer Agents from Marine Natural Substance

Anti-Cancer Agents in Medicinal Chemistry, 14(3): 409-417.

Author(s): Zhiguo Liu, Pengfei Xu, Tao Wu and Wenbin Zeng.

Affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, China


Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubuletargeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.


Anticancer, marine, microtubule, natural products.

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Article Details

Volume: 14
Issue Number: 3
First Page: 409
Last Page: 417
Page Count: 9
DOI: 10.2174/187152061403140207163402

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