Microtubule-targeting Anticancer Agents from Marine Natural Substance

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 14, 10 Issues, 2014


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 22nd of 58 in Chemistry, Medicinal
  • 85th of 202 in Oncology

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Microtubule-targeting Anticancer Agents from Marine Natural Substance

Author(s): Zhiguo Liu, Pengfei Xu, Tao Wu and Wenbin Zeng

Affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, China

Abstract

Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubuletargeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.

Keywords: Anticancer, marine, microtubule, natural products.

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Article Details

Volume: 14
Issue Number: 3
First Page: 409
Last Page: 417
Page Count: 9
DOI: 10.2174/187152061403140207163402
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