Phytochemical and Biological Activities of an Anticancer Plant Medicine: Brucea javanica

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 15, 10 Issues, 2015

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 29th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Phytochemical and Biological Activities of an Anticancer Plant Medicine: Brucea javanica

Anti-Cancer Agents in Medicinal Chemistry, 14(3): 440-458.

Author(s): Lijuan Zhao, Chao Li, Yao Zhang, Qing Wen and Dongmei Ren.

Affiliation: Department of Natural Products Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.


In this review, the literature data on recent advances of the medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae), both phytochemical and biological investigations, are compiled. Brucea javanica is an evergreen shrub distributed widely in Southeast Asia and northern Australia. In China, the seeds of Brucea javanica have been used as traditional herbal medicine due to its multifaceted activities. To date, 153 compounds have been reported from the seeds and aerial parts of Brucea javanica. Quassinoids are the main constituents of this species. The extract of Brucea javanica and the isolated compounds especially quassinoids exhibited various biological properties, such as antitumor and antimalarial effects.


Brucea javanica, biological activities, chemical constituents, quassinoids.

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Article Details

Volume: 14
Issue Number: 3
First Page: 440
Last Page: 458
Page Count: 19
DOI: 10.2174/18715206113136660336

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