Recent Advances in Small Molecule Prodrugs for Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 14, 10 Issues, 2014


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 22nd of 58 in Chemistry, Medicinal
  • 85th of 202 in Oncology

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Recent Advances in Small Molecule Prodrugs for Cancer Therapy

Author(s): Peng Wang, Xiao Jin, Jin Cai, Junqing Chen and Min Ji

Affiliation: School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, P.R. China.

Abstract

Chemotherapy has been performed to treat metastatic cancers but with varying degrees of success. The optimal potential of chemotherapy has not been achieved yet. Numerous compounds cannot be further developed to produce potent drugs because these compounds exhibit poor druggability. To resolve this issue, researchers developed prodrugs in drug discovery because these drugs can be efficiently used. Many small-molecule prodrugs have been designed and synthesized as anticancer agents for several years, and great progress has been achieved. In this study, recently developed, efficient anticancer prodrugs were reviewed, particularly small molecule prodrugs. Moreover, small molecule anticancer prodrugs were summarized according to different types of chemical structures and properties.

Keywords: Anticancer, cancer, prodrug, small molecule, therapy.

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Article Details

Volume: 14
Issue Number: 3
First Page: 418
Last Page: 439
Page Count: 22
DOI: 10.2174/18715206113139990317
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