Nature Promises New Anticancer Agents: Interplay with the Apoptosis-related BCL2 Gene Family

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 14, 10 Issues, 2014


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 26th of 59 in Chemistry, Medicinal
  • 99th of 197 in Oncology

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Nature Promises New Anticancer Agents: Interplay with the Apoptosis-related BCL2 Gene Family

Author(s): Maria-Ioanna Christodoulou, Christos K. Kontos, Maria Halabalaki, Alexios-Leandros Skaltsounis and Andreas Scorilas

Affiliation: Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens 15701, Greece.

Abstract

Natural products display special attributes in the treatment and prevention of a variety of human disorders including cancer. Their therapeutic capacities along with the fact that nature comprises a priceless pool of new compounds have attracted the interest of researchers worldwide. A significant number of organic compounds from terrestrial and marine organisms exhibit anticancer properties as attested by both in vitro and in vivo studies. Emerging evidence supporting the antineoplastic activity of natural compounds has rendered them promising agents in the fight against cancer. As a result, numerous natural compounds or their derivatives have entered clinical practice and are currently in the forefront of chemotherapeutics, showing beneficial effects for cancer patients. Induction of apoptosis seems to be the major mechanism of action induced by these natural agents in the race against cancer. This is mainly achieved through modulations of the expression of B-cell CLL/lymphoma 2 (BCL2) family members. These molecules appear to be the pivotal players determining cellular fate. In the current review, we provide a comprehensive overview of the major alterations in the gene and/or protein levels of BCL2-family members evoked in cancer cells after treatment with a gamut of natural compounds. The data cited suggest the need for exploitation of newly discovered natural products that, along with the improvement of currently employed chemotherapeutics, will significantly enrich the anticancer armamentarium.

Keywords: Alkaloids, antineoplastic agents, apoptosis, fatty acids, flavonoids, molecular tumor markers, natural products.

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Article Details

Volume: 14
Issue Number: 3
First Page: 375
Last Page: 399
Page Count: 25
DOI: 10.2174/18715206113139990089
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