Overcoming the Blood-Brain Barrier for Chemotherapy: Limitations, Challenges and Rising Problems

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 14, 10 Issues, 2014


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 22nd of 58 in Chemistry, Medicinal
  • 85th of 202 in Oncology

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Overcoming the Blood-Brain Barrier for Chemotherapy: Limitations, Challenges and Rising Problems

Author(s): Zhaoye Wang, Hui Sun and Juan Sebastian Yakisich

Affiliation: Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden, S-141 86.

Abstract

Treatment of brain tumors with chemotherapy is limited mostly because of delivery impediments related to the blood-brain barrier (BBB). For gliomas, the most common and aggressive primary brain tumor, treatment includes surgery, radiotherapy, and chemotherapy usually administered orally or intravenously. These routes do not deliver effective concentrations. To complicate matters, chemotherapy is usually a long treatment. Therefore, transient disruption of the BBB is likely insufficient to deliver effective intratumoral concentrations of anticancer drugs. This review briefly updates current strategies for overcoming the BBB with emphasis on their limitations and challenges intrinsic to the biology of cancer cells.




Keywords: Anticancer drugs, blood brain barrier, brain tumor, chemotherapy, gliomas.

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Article Details

Volume: 14
Issue Number: 8
First Page: 1085
Last Page: 1093
Page Count: 9
DOI: 10.2174/18715206113139990029
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