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Articles Ahead of Print
Abstracts Ahead of Print
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A. M. Zúñiga-Muñoz, V. Guarner, A. Díaz-Cruz, E. Diaz-Diaz, C. Nava-Cuellar, U. Beltrán-Rodríguez and I. Pérez-Torres
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[CMCIEMA-EPUB-20130521-1]
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Metabolic syndrome (MS) is associated with oxidative stress, both at early and advanced stages of the disease. Studies have confirmed the important role of medicinal plants or their active components in the prevention, treatment and lowering of risk factors in MS. Others authors have observed that polyphenols from Hibiscus sabdariffa L. (HSL) calyces increase cellular antioxidant capacity. We studied rat groups: Control (C), C plus 30 g per liter of HSL calyces infusion (C+HSL 3%), 30 % Sucrose-fed (MS) in their drinking water and 30 % Sucrose fed plus HSL calyces infusion (MS+HSL) at the concentration of 7.5, 15 and 30 g per liter. The administration of HSL infusion to the MS rats increased the concentration of antioxidant capacity, catalase, superoxide dismutase and peroxidases activity enzymes in a dependent way, while the activity of glutathione peroxidase decreased in the liver. Indices of lipid peroxidation and protein carbonylation decreased in the liver, and systolic blood pressure, body weight, intra-abdominal fat and serum levels of glycation, triglycerides, insulin and HOMA index also decreased. These results suggest that the treatment with HSL infusion may decrease oxidative stress in MS liver and that it could be regarded as an alternative treatment for MS.
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N. Ashigaki, J. -I Suzuki, M. Ogawa, R. Watanabe, N. Aoyama, N. Kobayashi, Y. Hirata, I. Komuro, Y. Izumi and M. Isobe
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[CMCIEMA-EPUB-20130412-2]
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Periodontitis is associated with several systemic disorders, such as diabetes, cardiovascular disease and chronic kidney disease (CKD). However, the pathophysiological relationship between periodontitis and CKD is yet to be elucidated. We assessed the hypothesis that periodontal bacteria influences renal dysfunction. We used C57BL/6J mice and implanted chambers subcutaneously in the back of each mouse. Two weeks after implantation, we injected Porphyromonas gingivalis (P.g.), which is a major periodontal pathogen, or phosphate-buffered saline (PBS) into the chamber. The subcutaneous injections were performed once a week for 6 weeks during the observation period. 5/6 nephrectomy (NTX) was made by a two-step surgical procedure. The levels of anti-P.g. IgG in the serum were determined with an ELISA. After the operation, we measured serum creatinine using an enzymatic method. On day 28, mice were sacrificed and pathological evaluation was also performed. The repeated bacterial injections elevated the serum level of anti-P.g.IgG significantly. NTX increased the serum creatinine level (0.35 ± 0.02mg/dl) compared to native mice (0.15 ± 0.01mg/dl). Neither infection altered creatinine levels (P.g. 0.41 ± 0.04mg/dl) (n = 15) compared to the PBS injected group (n = 20). On days 1, 3 and 7, serum creatinine levels were significantly increased in the P.g. injected group compared to the PBS injected group. Of note, P.g. infection deteriorated 28 days survival rate (46.9%, p<0.05) compared to the PBS injected group (90.9%). It was suggested that periodontal pathogens deteriorated serum creatinine levels and the survival rate after NTX.
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