Biography: Dr. Guangpu Li is currently a professor with tenure in the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center (OUHSC), USA. He received a Ph.D. degree in molecular biology from Washington University in St. Louis, USA, in 1991, studying Sindbis virus replication. He completed post-doctoral research from the Department of Cell Biology and Physiology also at the Washington University in St. Louis, investigating the role of endosomal Rab GTPases such as Rab5 in the regulation of endocytosis and endosome fusion. Dr. Li became an assistant professor at OUHSC in 1996, an associate professor with tenure in 2004, and established a productive research program that identified a new Rab5-interacting protein (PRA1 or prenylin), characterized the GTP hydrolysis mechanism of Rab5, and in collaboration with Drs. H Qian and XC Zhang, developed mathematical models to explain the GTP hydrolysis and activation mechanisms of Rab5 and determined crystal structures of Rab5, mutants, and Rab5-effector complexes. In recent years, Dr. Li’s laboratory has revealed functional divergence between the early endosome-associated Rab5 and Rab22 in the regulation of NGF signal transduction and cell differentiation. Dr. Li’s current research program is focused on the functions of endosomal Rab GTPases in the biogenesis of signaling endosomes and regulation of cell growth and differentiation. |