Post-traumatic inflammation is formed by molecular and cellular complex
mechanisms whose final goal seems to be injured tissue regeneration. In the skin, an
exterior organ of the body, mechanical or thermal injury induces the expression of
different inflammatory phenotypes that resemble similar phenotypes expressed during
embryo development. Particularly, molecular and cellular mechanisms are involved in
gastrulation return. This is a developmental phase that delineates the three embryonic
germ layers: ectoderm, endoderm and mesoderm. Consequently, in the post-natal
wounded skin primitive functions related with the embryonic mesoderm, i.e. amniotic
and yolk sac-derived, are expressed. Among the primitive function mechanisms
involved, neurogenesis and hematogenesis stand out as the prominent ones.
Interestingly, in these phases of the inflammatory response, whose molecular and
cellular mechanisms are considered as traces of the early phases of the embryonic
development, the mast cell, a cell that is supposedly inflammatory, plays a key role. The
correlation that can be established between the embryonic and the inflammatory events
suggests that the results obtained from the research regarding both great fields of
knowledge must be interchangeable to obtain the maximum advantage.
Keywords: Mesoderm, endoderm, ectoderm, amniotic, yolk sac, mesenchyma,
granulation tissue, gastrulation, wound repair, angiogenesis, inflammatory pain,
fetal, embryonic, remodeling.
