Abstract
1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial property. Their precise mechanism of action is not known but it is postulated that they act by inhibiting the biosynthesis of certain prostaglandins. 1, 3, 4-oxadiazoles are a class of heterocyclic compounds with wide variety of biological and pharmacological activities. They have been reported to possess analgesic, antimicrobial, antipyretic and anti-inflammatory properties. These compounds are also active against a number of other inflammatory conditions such as arthritis, gout etc. A wide variety of these compounds have been synthesized and some of them are under clinical trials. In this review article, anti-inflammatory and antimicrobial activity of the 1, 3, 4- oxadiazole shall be discussed.
Keywords: Oxadiazole derivatives, 1, 3, 4-oxadiazole, Inflammation, Anti-inflammatory, Heterocyclic compounds, Antimicrobial.
Current Organic Synthesis
Title:Anti-Inflammatory and Antimicrobial Potential of 1, 3, 4-Oxadiazoles and its Derivatives: A Review
Volume: 21 Issue: 8
Author(s): Tarun Chaudhary*, Prabhat Kumar Upadhyay and Ritu Kataria
Affiliation:
- Department of Medicinal Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, 281406, Uttar Pradesh, India
Keywords: Oxadiazole derivatives, 1, 3, 4-oxadiazole, Inflammation, Anti-inflammatory, Heterocyclic compounds, Antimicrobial.
Abstract: 1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial property. Their precise mechanism of action is not known but it is postulated that they act by inhibiting the biosynthesis of certain prostaglandins. 1, 3, 4-oxadiazoles are a class of heterocyclic compounds with wide variety of biological and pharmacological activities. They have been reported to possess analgesic, antimicrobial, antipyretic and anti-inflammatory properties. These compounds are also active against a number of other inflammatory conditions such as arthritis, gout etc. A wide variety of these compounds have been synthesized and some of them are under clinical trials. In this review article, anti-inflammatory and antimicrobial activity of the 1, 3, 4- oxadiazole shall be discussed.
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Cite this article as:
Chaudhary Tarun*, Upadhyay Prabhat Kumar and Kataria Ritu, Anti-Inflammatory and Antimicrobial Potential of 1, 3, 4-Oxadiazoles and its Derivatives: A Review, Current Organic Synthesis 2024; 21 (8) . https://dx.doi.org/10.2174/0115701794265887231014061317
DOI https://dx.doi.org/10.2174/0115701794265887231014061317 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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