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Current Drug Therapy

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ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

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Review Article

Lysosomal Storage Diseases: Natural Products Inducing Autophagy

Author(s): Chandani Chandarana*, Tahib Habshi, Arun Soni and Sanjeev Acharya

Volume 19, Issue 5, 2024

Published on: 26 September, 2023

Page: [546 - 560] Pages: 15

DOI: 10.2174/1574885519666230915103100

Price: $65

Abstract

Background: The link between autophagy and lysosomal function has been wellrecognised in recent decades; defective autophagy and lysosomal function lead to various disorders, notably Lysosomal Storage Disorders (LSDs). The malfunction of multiple mechanistic pathways influences the contribution of LSDs. Different ways are employed in such situations, but one novel approach could resolve the problem by inducing the autophagic pathway, which aids in maintaining proper autophagy and lysosomal degradation function.

Methods: Autophagic Inducer functions on the activation of Transcriptional factor EB (TFEB) and its mechanism; mTOR Complex Inhibition dependently or independently may repair the malfunction of the entire mechanism. Finding a potential autophagic inducer is still a work in progress, but targeting TFEB and mTOR could redefine LSD treatment. The development of experimentally available TFEB modulators could enhance autophagic flux promote lysosomal function and increase lysosomal biogenesis and can be a promising technique for treating illnesses caused by ALP dysfunction, such as lysosomal storage disorder.

Results: MTORC1 suppression causes TFEB to be transported to the nucleus and transcription of multiple genes involved in the formation of autophagosomes and lysosomes, indicating that MTORC1 has positive effects in treating lysosomal storage diseases such as Pompe disease, Batton disease, Fabry disease, etc. thus modulating autophagy attenuates the above condition.

Conclusion: This review comprises autophagy and lysosome association, and their malfunction leads to various lysosomal diseases. Several natural products are also discussed, which can be possible treatment options.

Keywords: Autophagy, lysosomal function, lysosomal storage disorder, transcriptional factor EB, mammalian target for rapamycin, natural autophagy inducers.

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