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ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

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Research Article

Preclinical Appraisal of the Aphrodisiac Effects of Emblica officinalis Seed Extract on Stress-induced Sexual Behavior in Albino Rats

Author(s): Sunil Kumar Kadiri, Deepak S. Khobragade* and Samaresh Pal Roy

Volume 19, Issue 5, 2024

Published on: 15 August, 2023

Page: [594 - 603] Pages: 10

DOI: 10.2174/1574885518666230804113303

open access plus

Abstract

Background: The king of herbs, Emblica officinalis, is one of the most important herbs in Ayurveda. It contains significant amounts of Vitamin C and has been reported to have antioxidant, anticancer, antiretroviral, antidepressant, antiulcerogenic, wound healing, and many other medicinal properties.

Objective: The current study is designed to investigate the aphrodisiac effects of E. officinalis seed extract on albino Wistar rats as well as its effects on stress-related sexual behaviour.

Materials and Methods: The aphrodisiac effect of E. officinalis was evaluated by mating the pretreated male rats with female rats. For 30 days, test group rats (n=6) were given methanolic extracts (95%) from E. officinalis seeds (500 and 1000 mg/kg). Control rats received saline. Standard group rats received testosterone (0.5 mg/ kg, i.m). The sexual behavior study tracked Mount Latency (ML), Intromission Latency (IL), Mounting Frequency (MF), Intromission Frequency (IF), sniffing, and licking on days 0 through 30. After 30 days, rats were sacrificed, and the anabolic effect was assessed using body weight, reproductive organ weight, sperm concentration, and histopathology of the testes. The stress was induced by immobilization stress in the stress-affected alteration in the sexual behavior model, and the above procedure was repeated for evaluation.

Results: The 95% methanolic extract (1000 mg/kg) of E. officinalis significantly reduced ML and IL while significantly increasing MF, IF, sniffing, licking, body weight, reproductive organ weight, and sperm concentration. Methanolic extract of E. officinalis increased sexual activities in the stress-free group and restored the stress-affected group's altered sexual behaviour.

Conclusion: The current study's findings indicate that 95% methanolic extract of E. officinalis has dose-dependent aphrodisiac activity and restores sexual behavior in a stress-induced group.

Keywords: Emblica officinalis, aphrodisiac, mounting, intromission, sniffing, licking, sperm, testosterone, rats.

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[1]
Patil SA, Sujaya M, Patil SB. Aphrodisiac and phytochemical studies of Cocculus hirsutus extracts in albino rats. Asian Pac J Reprod 2014; 3(1): 23-9.
[http://dx.doi.org/10.1016/S2305-0500(13)60180-3]
[2]
Ajao AA, Sibiya NP, Moteetee AN. Sexual prowess from nature: A systematic review of medicinal plants used as aphrodisiacs and sexual dysfunction in sub-Saharan Africa. S Afr J Bot 2019; 122: 342-59.
[http://dx.doi.org/10.1016/j.sajb.2018.08.011]
[3]
Goni O, Khan MF, Rahman MM, et al. Pharmacological insights on the antidepressant, anxiolytic and aphrodisiac potentials of Aglaonema hookerianum Schott. J Ethnopharmacol 2021; 268: 113664.
[http://dx.doi.org/10.1016/j.jep.2020.113664] [PMID: 33278545]
[4]
Busza J, Besana GVR, Mapunda P, Oliveras E. “I have grown up controlling myself a lot.” Fear and misconceptions about sex among adolescents vertically-infected with HIV in Tanzania. Reprod Health Matters 2013; 21(41): 87-96.
[http://dx.doi.org/10.1016/S0968-8080(13)41689-0] [PMID: 23684191]
[5]
Singh R, Ali A, Jeyabalan G, Semwal A. Current status of Indian medicinal plants with aphrodisiac potential. J Acute Dis 2013; 2(1): 13-21.
[http://dx.doi.org/10.1016/S2221-6189(13)60088-8]
[6]
Shamloul R. Natural aphrodisiacs. J Sex Med 2010; 7(1): 39-49.
[http://dx.doi.org/10.1111/j.1743-6109.2009.01521.x] [PMID: 19796015]
[7]
Gerbild H, Areskoug-Josefsson K, Larsen CM, Laursen BS. Acceptability of Health professionals’ address of sexuality and erectile dysfunction - a qualitative interview study with men in cardiac rehabilitation. Sex Med 2021; 9(3): 100369.
[http://dx.doi.org/10.1016/j.esxm.2021.100369] [PMID: 34087535]
[8]
Kohn TP, Rajanahally S, Hellstrom WJ, Hsieh TC, Raheem OA. Global trends in prevalence, treatments, and costs of penile prosthesis for erectile dysfunction in men. Eur Urol Focus 2022; 8(3): 803-13.
[http://dx.doi.org/10.1016/j.euf.2021.05.003] [PMID: 34034995]
[9]
Knouse MC, Briand LA. Behavioral sex differences in cocaine and opioid use disorders: The role of gonadal hormones. Neurosci Biobehav Rev 2021; 128: 358-66.
[http://dx.doi.org/10.1016/j.neubiorev.2021.06.038] [PMID: 34214512]
[10]
Ho TC, Colich NL, Sisk LM, Oskirko K, Jo B, Gotlib IH. Sex differences in the effects of gonadal hormones on white matter microstructure development in adolescence. Dev Cogn Neurosci 2020; 42: 100773.
[http://dx.doi.org/10.1016/j.dcn.2020.100773] [PMID: 32452463]
[11]
Delevich K, Piekarski D, Wilbrecht L. Neuroscience: Sex hormones at work in the Neocortex. Curr Biol 2019; 29(4): R122-5.
[http://dx.doi.org/10.1016/j.cub.2019.01.013] [PMID: 30779899]
[12]
Mong JA, Pfaff DW. Hormonal and genetic influences underlying arousal as it drives sex and aggression in animal and human brains. Neurobiol Aging 2003; 24 (Suppl. 1): S83-8.
[http://dx.doi.org/10.1016/S0197-4580(03)00053-8] [PMID: 12829115]
[13]
Ballard DJ. Treatment of erectile dysfunction: Can pelvic muscle exercises improve sexual function? J Wound Ostomy Continence Nurs 1997; 24(5): 255-64.
[http://dx.doi.org/10.1097/00152192-199709000-00012] [PMID: 9376901]
[14]
Neychev V, Mitev V. Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction. J Ethnopharmacol 2016; 179: 345-55.
[http://dx.doi.org/10.1016/j.jep.2015.12.055] [PMID: 26727646]
[15]
Almatroodi SA, Alsahli MA, Almatroudi A, et al. Amla (Emblica officinalis): Role in health management via controlling various biological activities. Gene Rep 2020; 21: 100820.
[http://dx.doi.org/10.1016/j.genrep.2020.100820]
[16]
Vimala Y, Rachel KV, Pramodini Y, Umasankar A. Usage of indian gooseberry (Emblica officinalis) seeds in health and diseaseNuts and Seeds in Health and Disease Prevention. Amsterdam: Elsevier Inc. 2011.
[http://dx.doi.org/10.1016/B978-0-12-375688-6.10077-5]
[17]
Ahmad B, Hafeez N, Rauf A, et al. Phyllanthus emblica: A comprehensive review of its therapeutic benefits. S Afr J Bot 2021; 138: 278-310.
[http://dx.doi.org/10.1016/j.sajb.2020.12.028]
[18]
Variya BC, Bakrania AK, Patel SS. Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. Pharmacol Res 2016; 111: 180-200.
[http://dx.doi.org/10.1016/j.phrs.2016.06.013] [PMID: 27320046]
[19]
Adler UC. Low-grade inflammation in chronic diseases: An integrative pathophysiology anticipated by homeopathy? Med Hypotheses 2011; 76(5): 622-6.
[http://dx.doi.org/10.1016/j.mehy.2010.12.019] [PMID: 21277692]
[20]
Sairam K, Rao ChV, Babu MD, Kumar KV, Agrawal VK,K, Goel RK. Antiulcerogenic effect of methanolic extract of Emblica officinalis: An experimental study. J Ethnopharmacol 2002; 82(1): 1-9.
[http://dx.doi.org/10.1016/S0378-8741(02)00041-7] [PMID: 12169398]
[21]
Harborne AJ. Phytochemical methods a guide to modern techniques of plant analysis. Heidelberg: Springer 1984.
[http://dx.doi.org/10.1016/0048-4059(85)90073-6]
[22]
Ramachandran S, Sridhar Y, Kishore Gnana Sam S, et al. Aphrodisiac activity of Butea frondosa Koen. ex Roxb. extract in male rats. Phytomedicine 2004; 11(2-3): 165-8.
[http://dx.doi.org/10.1078/0944-7113-00343] [PMID: 15070167]
[23]
Chidrawar VR, Chitme HR, Patel KN, et al. Effects of Cynodondactylon on stress-induced infertility in male rats. J Young Pharm 2011; 3(1): 26-35.
[http://dx.doi.org/10.4103/0975-1483.76416] [PMID: 21607051]
[24]
Tang X, Olatunji OJ, Zhou Y, Hou X. In vitro and in vivo aphrodisiac properties of the seed extract from Allium tuberosum on corpus cavernosum smooth muscle relaxation and sexual behavior parameters in male Wistar rats. BMC Complement Altern Med 2017; 17(1): 510.
[http://dx.doi.org/10.1186/s12906-017-2008-5] [PMID: 29191197]
[25]
Palaniyappan V. "Evaluation of phytoconstituents and aphrodisiac activity of the fruits of Duriozibenthinuslinn". J Pharm Res 2009; 2(9): 1493-5.
[26]
Yakubu MT, Akanji MA, Oladiji AT. Male sexual dysfunction and methods used in assessing medicinal plants with aphrodisiac potentials. Pharmacogn Rev 2007; 1(1): 49-56.

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